Survival Hyporesponsiveness and Prolong Allograft Express Fas Ligand Induce Donor-Specific Dendritic Cells Genetically Engineered to
نویسندگان
چکیده
منابع مشابه
Induction of allospecific tolerance by immature dendritic cells genetically modified to express soluble TNF receptor.
The ability of dendritic cells (DC) to initiate immune responses or induce immune tolerance is strictly dependent on their maturation state. TNF-alpha plays a pivotal role in the differentiation and maturation of DC. Blockade of TNF-alpha action may arrest DC in an immature state, prolonging their window of tolerogenic opportunity. Immature DC (imDC) were transfected with recombinant adenovirus...
متن کاملBlocking of the B7-CD28 pathway increases apoptosis induced in activated T cells by in vitro-generated CD95L (FasL) positive dendritic cells.
D ENDRITIC cells (DC) that express high levels of MHC class II and costimu!atory molecules are the most potent antigen-presenting cells and the only population that can activate naive T cells. 1 Evidence has also accumulated, however, that DC can playa role in tolerance induction. Thus, thymic DC induce central tolerance to MHC antigens.: The ubiquitous presence of donor DC in long-surviving hu...
متن کاملDendritic Cells in Transplant Tolerance
Dendritic cells (DCs) are a heterogeneous family of professional APCs involved in priming adaptive immune responses. Donor DCs (direct pathway of allorecognition) and recipient DCs presenting processed donor major histocompatibility complex (MHC) as peptides (indirect pathway of allorecognition) participate actively in graft rejection by stimulating recipient T cell responses following organ tr...
متن کاملCharacterization of donor dendritic cells and enhancement of dc efflux with cc- chemokine ligand 21: a novel strategy to prolong islet allograft survival Received on 13 October 2006 and accetped in revised form 15 January 2007
Dendritic cells (DC) are the most potent antigen-presenting cells, yet little data are available on the differential characteristics of donor and recipient DC (dDC and rDC) during the process of islet allograft rejection. DTR-GFP-DC mice provide a novel tool to monitor DC trafficking and characteristics during allograft rejection. We show rapid migration of dDC to recipient lymphoid tissues as ...
متن کاملThe role of the CD40 pathway in alloantigen-induced hyporesponsiveness in vivo.
Resting B (rB) cells are known to be incompetent APCs in vitro, which alone can induce specific unresponsiveness to single minor histocompatibility (miH) Ags and, when combined with CD40 pathway blockade, can induce hyporesponsiveness to MHC molecules in vivo. Here we show that anti-CD40 ligand (CD40L) mAb does not prevent the expression of B7-2 on allogeneic rB cells in vivo but did prolong do...
متن کامل